Pervasive Transcription

A place to consolidate the mounting evidence for the biological significance of widespread RNA production by the genomes of humans and other organisms.


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PUBLICATIONS: (chronological listing)
Date Title Authors Source
2006 Transcriptional landscape of the human and fly genomes: nonlinear and multifunctional modular model of transcriptomes. Willingham AT, Dike S, Cheng J, Manak JR, Bell I, Cheung E, Drenkow J, Dumais E, Duttagupta R, Ganesh M, Ghosh S, Helt G, Nix D, Piccolboni A, Sementchenko V, Tammana H, Kapranov P; ENCODE Genes And Transcripts Group, Gingeras TR. Cold Spring Harb Symp Quant Biol. 71:101-10.
2007-02 Transcriptional noise and the fidelity of initiation by RNA polymerase II Struhl K Nature Structural & Molecular Biology, 14(2):103-5
2007-05-08 Genome-wide transcription and the implications for genomic organization Kapranov P, Willingham AT, Gingeras TR Nat Rev Genet 8 (6): 413-23
2007-05-17 RNA maps reveal new RNA classes and a possible function for pervasive transcription Kapranov P, Cheng J, Dike S, Nix DA, Duttagupta R, Willingham AT, Stadler PF, Hertel J, Hackermuller J, Hofacker IL, et al. Science 316 (5830): 1484-8
2007-06-14 Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project The ENCODE Project Consortium Nature 447, 799-816
2007-06 Genome Biology ENCODE pilot project companion issue (Assorted articles and authors) Genome Biol 17(6)
2007-07-13 A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells Guenther MG, Levine SS, Boyer LA, Jaenisch R, Young RA Cell 130, 77-88
2008-05-30 Mapping and quantifying mammalian transcriptomes by RNA-Seq; (supplementary materials) Mortazavi A, Williams BA, McCue1 K, Schaeffer L, Wold B Nature Methods 5:621-628.
2008-06-06 The Transcriptional Landscape of the Yeast Genome Defined by RNA Sequencing Nagalakshmi U, Wang Z, Waern K, Shou C, Raha D, Gerstein M, Snyder M Science 320 (5881): 1344-1349
2009 Pervasive transcription in the human genome Choudhuri S, Carlson DB Genomics: Fundamentals and Applications, Section 4.1.10.1, pp.80-82.
2009-01 RNA-Seq: a revolutionary tool for transcriptomics Wang Z, Gerstein M, Snyder M. Nat Rev Genet. 10(1):57-63.
2009-02-19 Bidirectional promoters generate pervasive transcription in yeast. Xu Z, Wei W, Gagneur J, Perocchi F, Clauder-Münster S, Camblong J, Guffanti E, Stutz F, Huber W, Steinmetz LM. Nature 457(7232):1033-7.
2009-05-11 Studying chromosome-wide transcriptional networks: new insights into disease? Kapranov, K Genome Medicine 1:50
2009-06-17 Unlocking the secrets of the genome Celniker SE, Dillon LAL, Gerstein MB, Gunsalus KC, Henikoff S, Karpen GH, Kellis M, Lai EC, Lieb JD, MacAlpine DM, Micklem G, Piano F, Snyder M, Stein L, White KP, Waterston RH, and the modENCODE Consortium. Nature 459: 927-930
2009-08-14 Pervasive transcription constitutes a new level of eukaryotic genome regulation (review) Berretta J and Morillon A EMBO reports 10(9): 973–982
2009-09-21 Pervasive transcription of the eukaryotic genome: functional indices and conceptual implications Dinger ME, Amaral PP, Mercer TR, Mattick JS Briefings in Functional Genomics and Proteomics, Advance Access
2009-12 The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs Jacquier A Nat Rev Genet 10: 833-844
2010-12-21 The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA Kapranov P, St. Laurent G, Raz T, Ozsolak F, Reynolds C, Sorensen P, Reaman G, Milos P, Arceci R, Thompson J, Triche T BMC Biology 8: 149
2011-09 Regulatory Variation Within and Between Species Zheng W, Gianoulis TA, Karczewski KJ, Zhao H, Snyder M Annual Review of Genomics and Human Genetics, vol 12

POPULAR PRESS/BLOGS: (chronological listing)
Date Title Authors Source
2007-05-17 New RNA Muddies Gene Definition: Mysterious RNA may control gene activity in unnoticed ways Minkel JR Scientific American, May 2007
2007-05-19 Another Layer of Complexity: Short lengths of RNA could provide new form of genetic control Barry P Science News, Vol.171 (20): 309
2007-06-13 ENCODE finds the human genome to be an active place Timmer J Ars Technica
2008-08-27 Genetics: The production line (Nature News Feature, requires subscription) Petherick A Nature 454: 1042-1045
2008-11-11
Now: The Rest of the Genome Zimmer C New York Times, Science Times feature, 11 Nov 2008
The Promise and Power of RNA Pollack A
A Bestiary of RNA Corum J
2010-12-17 Shining a Light on the Genome's 'Dark Matter' Pennisi E Science "Insights of the Decade", Vol. 330 (6011): 1614
2011-01-08 Next Generation Sequencing adds thousands of new genes Porter S ScienceBlogs.com

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